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Experimental evidence suggests that salivary concentrations of acetaldehyde, the genotoxic byproduct of alcohol metabolism, are greatly increased by tobacco smoking 43 , which could result in enhanced alcohol-related mutagenesis in cases with combined exposure

It is true that Thompson's work was uneven especially in his later years but if you doubt his abilities as a satirist you might look up his obituary of Richard Nixon, delivered from the Jerome stage by his friend Shelby Sadler, who is a former speechwriter for George Bush Sr

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